Faculty

Research Papers

• Halogenated Hypoxanthine 2’-Deoxyribonucleosides With Pyrazolo[3,4-d]Pyrimidine Skeleton: Synthesis, Crystal Structures, Physical Properties, and Impact on Watson-Crick and Purine-Purine Base Pairs. Dasharath Kondhare, Simone Budow-Busse, Constantin Daniliuc, Peter Leonard. Chem. Eur. J., 2025; 0:e03204 (1 to 18).
• Xanthine base pairing with 2-Aminoadenine and Canonical bases in purine tracts of Watson-Crick DNA: Impact of purine, 7-Deazapurine and 8-Aza-7-deazapurine heterocyclic skeletons on duplex stability. Dasharath Kondhare, Matthias Letzel, PeterLeonard. Chem. Eur. J.2025, 0, e01227 (1 to 16).
• Bioorthogonal Functionalization in the Minor Groove of DNA: Inverse-Electron Demand Diels Alder Reactions with Cyclopropenyl and Heptenoyl Protected 2-Amino-2’-deoxyadenosine as Target Site. Zhenqiang Xia, Dasharath Kondhare, Sushma Deshmukh, Somnath Chandankar, and Peter Leonard. Chem. Eur. J., 2025. 0, e202500529 (1 to 15). (Equal contribution)
• 8-Ethynyl-2’-deoxyisoguanosine with two tautomeric forms in the unit cell: crystal structure, packing and Hirshfeld surface analysis. Dasharath Kondhare, Simone Budow-Busse, Constantin G. Daniliuc and Peter Leonard. Acta Cryst., 2025, C81, 1-8.
• 7-Alkynylated and 7-halogenated 7-deazapurine-2,6-diamine 2’-deoxyribonucleosides: Crystal structure, hirshfeld surface analysis, functionalization and physical properties Zhenqiang Xia, Dasharath Kondhare, Simone Budow-Busse, Constantin Daniliuc, Yang He, Peter Leonard. J. Mol. Struct., 2025, 1333, 141713. (Equal contribution)
• Xanthine Nucleosides with Pyrazolo[3,4-d]pyrimidine Skeleton: Functionalization with Halogen Atoms, Clickable Side Chains, Pyrene and iEDDA Cycloadducts and Impact of Ionic Forms on Photophysical Properties. Dasharath Kondhare, Simone Budow-Busse, Constantin Daniliuc and Peter Leonard. J. Org. Chem., 2025, 90, 2, 1096-1114.
• α-D Nucleoside Based Self-Healing Supramolecular Hydrogels derived from the α-D Anomers of 2'-Deoxyguanosine and Fluorescent 8-Azapurine 2’-Deoxyribofuranosides. Sushma Deshmukh, Simone Budow-Busse, Dasharath Kondhare, Andreas H. Schäfer, Peter Leonard, Frank Seela. Chem. Eur. J., 2025, e202403282 (1-16).
• 7-Deaza-2’-deoxyisoguanosine, a Non-Canonical Nucleoside for Nucleic Acid Code Expansion and New DNA Constructs: Nucleobase Functionalization of Inverse Watson-Crick and Purine-Purine Base Pairs. Zhenqiang Xia, Dasharath Kondhare, Simone Budow-Busse, Peter Leonard, Frank Seela, Bioconj. Chem., 2024, 35, 1233-1250.
• 7-Deazapurine and Pyrimidine Nucleoside and Oligonucleotide Cycloadducts Formed by Inverse Diels-Alder Reactions with 3,6-Di(pyrid-2-yl)-1,2,4,5-tetrazine: Ethynylated and Vinylated Nucleobases for Functionalization and Impact of Pyridazine Adducts on DNA Base Pair Stability and Mismatch Discrimination. Somnath Chandankar, Dasharath Kondhare, Sushma Deshmukh, Haozhe Yang, Peter Leonard and Frank Seela, J. Org. Chem., 2024, 89, 11304-11322. (Equal contribution)
• Nucleobase-Functionalized 7-Deazaisoguanine and 7-Deazapurin-2,6-diamine Nucleosides: Halogenation, Cross-Coupling and Cycloaddition. Zhenqiang Xia, Dasharath Kondhare, Somnath Chandankar, Sachin Ingale, Peter Leonard and Frank Seela. J. Org. Chem., 2024, 89, 807-822.
• Purine DNA Constructs Designed to Expand the Genetic Code: Functionalization, Impact of Ionic Forms, and Molecular Recognition of 7-Deazaxanthine−7-Deazapurine-2,6-diamine Base Pairs and Their Purine Counterparts. Somnath S. Chandankar, Dasharath Kondhare, Peter Leonard, and Frank Seela. J. Org. Chem., 2023, 88, 13149-13168.
• Watson-Crick Base Pairs with Protecting Groups: The 2-Amino Groups of Purine- and 7-Deazapurine-2,6-diamine as Target Sites for DNA Functionalization by Selective Nucleobase Acylation. Dasharath Kondhare, Xenia Heddinga, Peter Leonard and Frank Seela. Bioconj. Chem., 2023, 34, 1290.
• The 2’-C-Methylribonucleoside of 5-Aza-7-deaza-7-iodoguanine: Hydrogen and Halogen Bonding in Nucleoside Crystals, Synthesis and Physical Properties. Dasharath Kondhare, Xenia Heddinga, Simone Budow-Busse, Constantin Daniliuc and Frank Seela, J. Mol. Struct., 2023, 1286, 135535.
• The Base Pairs of Isoguanine and 8-Aza-7-deazaisoguanine with 5-Methylisocytosine as Targets for DNA Functionalization. Dasharath Kondhare, Peter Leonard and Frank Seela. Bioconj. Chem., 2023, 34, 2, 422-432.
• DNA with Purine-Purine Base Pairs: Size and Position of Isoguanine and 8-Aza-7-deazaisoguanine Clickable Residues Control the Molecular Recognition of Guanine and 5-Aza-7-deazaguanine. Dasharath Kondhare, Aigui Zhang, Peter Leonard and Frank Seela. J. Org. Chem., 2022, 87, 10630-10650.
• DNA Strand Displacement with Base Pair Stabilizers: Purine-2,6-diamine and 8-Aza-7-bromo-7-deazapurine-2,6-diamine Oligonucleotides Invade Canonical DNA and New Fluorescent Pyrene Click Sensors Monitor the Reaction. Aigui Zhang, Dasharath Kondhare, Peter Leonard and Frank Seela. Chem. Eur. J., 2022, 28, e202202412. (Equal contribution)
• Purine-Purine Base Pairs in Parallel DNA: β-D Anomeric 8-Aza-7-deazaisoguanine and 7-Functionalized Conjugates Form Stable Base Pairs with α-D 5-Aza-7-deaza-2’-deoxyguanosine. Aigui Zhang, Dasharath Kondhare, Peter Leonard and Frank Seela. Bioconj. Chem., 2022, 33, 1796-1802. (Equal contribution)
• Anomeric DNA Strand Displacement with α-D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β-, β/β- and α/α-D Configuration. Aigui Zhang, Dasharath Kondhare, Peter Leonard and Frank Seela. Chemistry Eur. J., 2022, 28, e202201394. (Equal contribution)
• The 2'-deoxyribofuranoside of tetrahydro-3-phenyl-pyrimido[4,5-c]pyridazin-7-one: a bicyclic nucleoside with sugar residues in N and S conformation and its molecular recognition. Hui Mei, Simone Budow-Busse, Dasharath Kondhare, Henning Eickmeier, Hans Reuter and Frank Seela. Acta Cryst., 2022, C78, 382-389.
• 8-Furyl-imidazolo-2’-deoxycytidine: crystal structure, packing, atropisomerism and fluorescence. Simone Budow-Busse, Sunit K. Jana, Dasharath Kondhare, Constantin Daniliuc and Frank Seela. Acta Cryst., 2022, C78, 141-147.
• Isoguanine (2-Hydroxyadenine) and 2-Aminoadenine Nucleosides with an 8-Aza-7-deazapurine Skeleton: Synthesis, Functionalization with Fluorescent and Clickable Side Chains, and Impact of 7-Substituents on Physical Properties. Dasharath Kondhare, Peter Leonard, and Frank Seela. J. Org. Chem. 2021, 86, 21, 14461-14475.
• Eco-efficient one-pot tandem synthesis of 1-aryl-1H-tetrazol-5-amine by CAN via in situ generated 1-phenylthiourea and heterocumulene. Dasharath D. Kondhare, Venkat V. Bhadke, Sushma S. Deshmukh, Mahesh G. Wakhradkar, Balaji B. Totawar. J. Indian Chem. Soc. 2021, 98, 8, 100103.
• 5-Aza-7-deazaguanine-Isoguanine and Guanine-Isoguanine Base Pairs in Watson-Crick DNA: The Impact of Purine Tracts, Clickable Dendritic Side Chains and Pyrene Adducts. Aigui Zhang, Dasharath Kondhare, Peter Leonard and Frank Seela. Chem. Eur. J. 2021, 27, 7453-7466.
• The 2-Amino Group of 8-Aza-7-deaza-7-bromopurine-2,6-diamine and Purine-2,6-diamine as Stabilizer for the Adenine–Thymine Base Pair in Heterochiral DNA with Strands in Anomeric Configuration. Yingying Chai, Dasharath Kondhare, Aigui Zhang, Peter Leonard, and Frank Seela. Chem. Eur. J. 2020, 26, 1–12.
• Alkynylated and Dendronized 5-Aza-7-deazaguanine Nucleosides: Cross-Coupling with Tripropargylamine and Linear Alkynes, Click Functionalization, and Fluorescence of Pyrene Adducts. Dasharath Kondhare, Aigui Zhang, Peter Leonard, and Frank Seela. J. Org. Chem. 2020, 85, 10525−10538.
• 7-Iodo-5-aza-7-deazaguanine ribonucleoside: crystal structure, physical properties, base-pair stability and functionalization. Dasharath Kondhare, Simone Budow-Busse, Constantin Daniliuc and Frank Seela. Acta Cryst. 2020, C76, 513-523.
• Nucleobase-Functionalized 5-Aza-7-deazaguanine Ribo- and 2′-Deoxyribonucleosides: Glycosylation, Pd-Assisted Cross-Coupling, and Photophysical Properties. Peter Leonard, Dasharath Kondhare, Xenia Jentgens, Constantin Daniliuc, and Frank Seela. J. Org. Chem. 2019, 84, 13313−13328.
• Anomeric 5-Aza-7-deaza-2’-deoxyguanosines in Silver-Ion-Mediated Homo and Hybrid Base Pairs: Impact of Mismatch Structure, Helical Environment, and Nucleobase Substituents on DNA Stability. Xinglong Zhou, Dasharath Kondhare, Peter Leonard, and Frank Seela. Chem. Eur. J. 2019, 25, 10408–10419.
• Curcumin Analogues with Aldose Reductase Inhibitory Activity: Synthesis, Biological Evaluation, and Molecular Docking. Dasharath Kondhare, Sushma Deshmukh and Harshad Lade. Processes 2019, 7, 417.
• An efficient and facile synthesis of functionalized flavones from flavanones. Dasharath Kondhare, Anjaneyulu Kasa, Balaji Totawar, Venkat Bhadke & Harshad Lade. J Iran Chem Soc. 2019, 17, 639–647.
• An efficient synthesis of flavanones and their docking studies with aldose reductase. D. D. Kondhare, G. Gyananath, Yasinalli Tamboli, Santosh S. Kumbhar, Prafulla B. Choudhari, Manish S. Bhatia & P. K. Zubaidha. Med. Chem. Res. 2017, 26, 987–998.
• Phytochemical profile, aldose reductase inhibitory, and antioxidant activities of Indian traditional medicinal Coccinia grandis (L.) fruit extract. Kondhare, D., Lade, H. 3 Biotech 2017, 7, 378.
• Synthesis and evaluation of antioxidant activity of 2-styrylchromones. Pawar, S.P., Kondhare, D.D. & Zubaidha, P.K. Med. Chem. Res. 2013, 22, 753–757.
• Manganese (II) salts as efficient catalysts for chemo selective transesterification of β-keto esters under non-conventional conditions. G. Krishnaiah, B. Sandeep, D. Kondhare, K.C. Rajanna, J. Narendar Reddy, Y. Rajeshwar Rao, P. K. Zubaidha. Tetrahedron Lett. 2013, 54, 703.
• Calcium hydroxide: An efficient and mild base for one-pot synthesis of curcumin and its analogues. Pramod S. Kulkarni, Dasharath D. Kondhare, Ravi Varala, Pudukulathan K. Zubaidha. Acta Chimica Slovaca, 2013, 6(1), 150-156.
• Cyclization of 2′-hydroxychalcones to flavones using ammonium iodide as an iodine source – an eco-friendly approach. Pramod S. Kulkarni, Dasharath D. Kondhare, Ravi Varala and Pudululuthan K. Zubaidha. J. Serb. Chem. Soc. 2013, 78 (7) 909–916.

Projects

• Project Title: Applications of new routes to Indolizidine alkaloids: The total synthesis of Cyclizidine.
• Funding: Science and Engineering Research Board (SERB), New Delhi, Government of India.
• File No. & Year: SERB sanction order no. PDF/2016/001783 Dated: 05-05-2017.
• Amount sanctioned: Rs. 19,20,000=00.
• Principal Investigator: Dr. Dasharath Dattatray Kondhare.
• Mentor: Dr. S. Raghavan.
• Institute: CSIR–Indian Institute of Chemical Technology (IICT), Hyderabad, Telangana, India.

Conferences/Poster/seminar/Workshops

• Awarded Post-Doctoral Fellowship (PDF) from Chembiotech, Münster, Germany under Prof. Dr. Frank Seela (2018–2025).
• Awarded National Post-Doctoral Fellowship (NPDF) from SERB, Government of India under Dr. S. Raghavan, IICT Hyderabad (2017–2018).
• Awarded INSPIRE 1st Ranker Merit Fellowship from DST, Government of India (2010).